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Article

Mitochondrial DNA haplogroup background affects LHON, but not suspected LHON, in Chinese patients.

PloS one - 1 Jan 2011

Zhang A-Mei, Jia Xiaoyun, Bi Rui, Salas Antonio, Li Shiqiang, Xiao Xueshan, Wang Panfeng, Guo Xiangming, Kong Qing-Peng, Zhang Qingjiong, Yao Yong-Gang

Abstract excerpt

Recent studies have shown that mtDNA background could affect the clinical expression of Leber hereditary optic neuropathy (LHON). We analyzed the mitochondrial DNA (mtDNA) variation of 304 Chinese patients with m.11778G>A (sample #1) and of 843 suspected LHON patients who lack the three primary mutations (sample #2) to discern mtDNA haplogroup effect on disease onset. Haplogroup frequencies in the patient group...

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Identifiers

PMID: 22110754
DOI: 10.1371/journal.pone.0027750
PMCID: PMC3216987

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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