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Chronic lymphocytic leukemia immunoglobulins display bacterial reactivity that converges and diverges from auto-/poly-reactivity and IGHV mutation status.

Clinical immunology (Orlando, Fla.) - 1 Nov 2016

Hatzi Katerina, Catera Rosa, Moreno Atanasio Carolina, Fischetti Vincent A, Allen Steven L, Kolitz Jonathan E, Rai Kanti R, Chu Charles C, Chiorazzi Nicholas

Abstract excerpt

Chronic lymphocytic leukemia (CLL) is an incurable leukemia of unknown etiology. Multiple studies suggest that the structure of the variable domains of the surface IGs on these cells, and signaling through them, play key roles in developing the disease. Hence, CLL appears to be driven by antigen-BCR interactions, and identifying the selecting antigens involved in this process is an important goal. We studied the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27586592
DOI: 10.1016/j.clim.2016.08.020

Genes

BCR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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