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Article

In vitro ubiquitination of cyclin D1 by ROC1-CUL1 and ROC1-CUL3.

FEBS letters - 13 Apr 2001

Maeda I, Ohta T, Koizumi H, Fukuda M

Abstract excerpt

Overexpression of cyclin D1 has been implicated in a variety of tumors, such as breast cancers, gastrointestinal cancers and lymphomas. Both gene amplification and protein degradation mediated by ubiquitin (Ub)-dependent proteolysis regulate the abundance of cyclin D1. Here we report that ROC1 in...

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Share to Anaphase-Promoting Complex-Cyclosome
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Source

Identifiers

PMID: 11311237
DOI: 10.1016/s0014-5793(01)02343-2

Genes

CUL3
CUL1
CUL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026. Prepared record publication-11311237-2026-08-31.1. Manifest publication-graph-cohort-2026-08-31.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 31 Aug 2026.

Related research

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In vitro ubiquitination of cyclin D1 by ROC1-CUL1 and ROC1-CUL3.PMID 11311237Read ↗

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