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Article

Targeted disruption of Drosophila Roc1b reveals functional differences in the Roc subunit of Cullin-dependent E3 ubiquitin ligases.

Molecular biology of the cell - 1 Nov 2004

Donaldson Timothy D, Noureddine Maher A, Reynolds Patrick J, Bradford William, Duronio Robert J

Abstract excerpt

Cullin-dependent ubiquitin ligases regulate a variety of cellular and developmental processes by recruiting specific proteins for ubiquitin-mediated degradation. Cullin proteins form a scaffold for two functional modules: a catalytic module comprised of a small RING domain protein Roc1/Rbx1 and a ubiquitin-conjugating enzyme (E2), and a substrate recruitment module containing one or more proteins that bind to and...

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Identifiers

PMID: 15331761
DOI: 10.1091/mbc.e04-03-0180
PMCID: PMC524738

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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