Article
Cloning, characterisation and identification of several polymorphisms in the promoter region of the human alpha2B-adrenergic receptor gene.
Biochemical pharmacology - 1 Feb 2004
Cayla Cécile, Heinonen Paula, Viikari Liisa, Schaak Stéphane, Snapir Amir, Bouloumié Anne, Karvonen Matti K, Pesonen Ullamari, Scheinin Mika, Paris Hervé
Abstract excerpt
Screening of a foetal brain genomic DNA library allowed to isolate a 10-kb fragment of the gene encoding the human alpha2B-adrenergic receptor, that contained 5.5 kb of the 5'-flanking region, the open reading frame and 2.9 kb of the 3'-flanking region. The 1-kb fragment upstream from the start codon was rich in GC, lacked consensus TATA or CAAT box, but contained several Sp1-binding sites. Other potential...
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