Article
Influence of the cytochrome P4502D6*4 allele on the pharmacokinetics of controlled-release metoprolol.
European journal of clinical pharmacology - 1 Aug 1998
Koytchev R, Alken R G, Vlahov V, Kirkov V, Kaneva R, Thyroff-Friesinger U, Rehak E
Abstract excerpt
AIM: The aim of the present paper was to compare the pharmacokinetics of metoprolol in homozygous Caucasian volunteers for the wild-type CYP2D6 allele (CYP2D6*1/CYP2D6*1) and heterozygous (CYP2D6*1/CYP2D6*4) Caucasians. METHODS: Thirty-six unrelated healthy male Caucasians were screened for two o...
Topics
- Adrenergic beta-Antagonists
- Alleles
- Area Under Curve
- Chromatography, High Pressure Liquid
- Cross-Over Studies
- Cytochrome P-450 CYP2D6
- Delayed-Action Preparations
- Heterozygote
- Homozygote
- Humans
- Male
- Metoprolol
- Polymerase Chain Reaction
- Reference Values