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Article

K-ras and p53 mutations and overexpressions as prognostic factors in female rectal carcinoma.

Anticancer research - 1 Jan 2000

Hirvikoski P, Auvinen A, Servomaa K, Kiuru A, Rytömaa T, Makkonen K, Kosma V M

Abstract excerpt

BACKGROUND: The present study was undertaken to determine the prognostic significance of K-ras, p53 and bcl-2 in female rectal carcinoma. MATERIALS AND METHODS: The mutations in K-ras and p53 genes were analysed using SSCP and direct sequencing. The expression of K-ras, bcl-2 and p53 proteins was determined immunohistochemically. RESULTS: Mutations of K-ras and p53 genes were detected in 12% and 38% of the...

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PMID: 10216477

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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