Prognostic factors of colorectal cancer: K-ras mutation, overexpression of the p53 protein, and cell proliferative activity.

doi:10.1002/jso.2930570115

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Article

Prognostic factors of colorectal cancer: K-ras mutation, overexpression of the p53 protein, and cell proliferative activity.

Journal of surgical oncology - 1 Sept 1994

Tanaka M, Omura K, Watanabe Y, Oda Y, Nakanishi I

Abstract excerpt

Between June 1990 and April 1991, 62 colorectal tumors were assessed in a prospective fashion on the basis of various tumor characteristics. Parameters included K-ras mutation, overexpression of the p53 protein, and proliferating cell nuclear cell antigen, as well as standard histopathologic examination. A multivariate analysis showed that K-ras mutation correlated with vascular invasion (P < 0.01) and...

Topics

Adenoma
Analysis of Variance
Antigens, Neoplasm
Carcinoma
Colorectal Neoplasms
Female
Gene Expression Regulation, Neoplastic
Genes, ras
Humans
Immunohistochemistry
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Multivariate Analysis

Mutation

Nuclear Proteins

Predictive Value of Tests

Prognosis

Proliferating Cell Nuclear Antigen

Proportional Hazards Models

Source

Open in PubMed

Identifiers

PMID: 7914949
DOI: 10.1002/jso.2930570115

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7914949-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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