Article
Transcript splicing is essential for functional Histoplasma capsulatum URA5 expression.
Gene - 16 Apr 1999
Retallack D M, Woods J P
Abstract excerpt
The isolation of auxotrophic markers is important for molecular genetic studies of the dimorphic fungus Histoplasma capsulatum. We have isolated a UV-induced mutant of H. capsulatum, resulting in nonreverting uracil auxotrophy due to a mutation in the URA5 gene. In this study, we show that this mutation is a GG to TA conversion bordering the 5' donor splice site of intron 2. The mutation results in the lack of...
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