Insertional mutagenesis enables cleistothecial formation in a non-mating strain of Histoplasma capsulatum.

Abstract excerpt

BACKGROUND: Histoplasma capsulatum is a pathogenic ascomycete fungus that rapidly loses mating ability in culture. Loss of mating ability, as well as the organism's low rate of targeted gene replacement, limits techniques available for genetic studies in H. capsulatum. Understanding molecular mechanisms regulating mating in this organism may allow us to reverse or prevent loss of mating in H. capsulatum strains,...

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