Identifying Phase-specific Genes in the Fungal Pathogen<i>Histoplasma capsulatum</i>Using a Genomic Shotgun Microarray

Abstract excerpt

A fundamental feature of the fungal pathogen Histoplasma capsulatum is its ability to shift from a mycelial phase in the soil to a yeast phase in its human host. Each form plays a critical role in infection and disease, but little is understood about how these two morphologic phases are established and maintained. To identify phase-regulated genes of H. capsulatum, we carried out expression analyses by using a...

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