Article
A role for DNA-PK in retroviral DNA integration.
Science (New York, N.Y.) - 23 Apr 1999
Daniel R, Katz R A, Skalka A M
Abstract excerpt
Retroviral DNA integration is catalyzed by the viral protein integrase. Here, it is shown that DNA-dependent protein kinase (DNA-PK), a host cell protein, also participates in the reaction. DNA-PK-deficient murine scid cells infected with three different retroviruses showed a substantial reduction in retroviral DNA integration and died by apoptosis. Scid cell killing was not observed after infection with an...
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