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DNA-Dependent Protein Kinase Is Not Required for Efficient Lentivirus Integration

1 Dec 2000

Abstract excerpt

How DNA is repaired after retrovirus integration is not well understood. DNA-dependent protein kinase (DNA-PK) is known to play a central role in the repair of double-stranded DNA breaks. Recently, a role for DNA-PK in retroviral DNA integration has been proposed (R. Daniel, R. A. Katz, and A. M. Skalka, Science 284:644-647, 1999). Reduced transduction efficiency and increased cell death by apoptosis were...

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Identifiers

PMID: 11070027
DOI: 10.1128/jvi.74.23.11278-11285.2000

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