Article
MDM2 and MDMX bind and stabilize the p53-related protein p73.
Current biology : CB - 1 Jan 2000
Ongkeko W M, Wang X Q, Siu W Y, Lau A W, Yamashita K, Harris A L, Cox L S, Poon R Y
Abstract excerpt
The p53 gene encodes one of the most important tumor suppressors in human cells and undergoes frequent mutational inactivation in cancers. MDM2, a transcriptional target of p53, binds p53 and can both inhibit p53-mediated transcription [1] [2] and target p53 for proteasome-mediated proteolysis [3] [4]. A close relative of p53, p73, has recently been identified [5] [6]. Here, we report that, like p53, p73alpha and...
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