Article
Haptoglobin genotype and the rate of renal function decline in the diabetes control and complications trial/epidemiology of diabetes interventions and complications study.
Diabetes - 1 Sept 2013
Orchard Trevor J, Sun Wanjie, Cleary Patricia A, Genuth Saul M, Lachin John M, McGee Paula, Paterson Andrew D, Raskin Philip, Anbinder Yefim, Levy Andrew P
Abstract excerpt
Many patients with type 1 diabetes develop renal disease despite moderately good metabolic control, suggesting other risk factors may play a role. Recent evidence suggests that the haptoglobin (HP) 2-2 genotype, which codes for a protein with reduced antioxidant activity, may predict renal function decline in type 1 diabetes. We examined this hypothesis in 1,303 Caucasian participants in the Diabetes Control and...
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