Article
Developmental basis of retinal-specific induction of cancer by RB mutation.
Cancer research - 1 Apr 1999
Gallie B L, Campbell C, Devlin H, Duckett A, Squire J A
Abstract excerpt
Understanding why children with RB mutations specifically develop retinoblastoma will contribute to the understanding of the fundamental principles of cancer. Only a subset of developing retinal cells are at risk for developing cancer when RB is mutant because rod photoreceptor and bipolar cells never normally express RB. Retinoblastomas are observed to arise commonly in the inner nuclear layer, where they can...
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