Article
Codon 17 polymorphism of the cytotoxic T lymphocyte antigen 4 gene in Hashimoto's thyroiditis and Addison's disease.
The Journal of clinical endocrinology and metabolism - 1 Dec 1997
Donner H, Braun J, Seidl C, Rau H, Finke R, Ventz M, Walfish P G, Usadel K H, Badenhoop K
Abstract excerpt
Endocrine autoimmune disorders share susceptibility and resistance factors of the human leukocyte antigen system on the short arm of chromosome 6, but other gene loci also contribute to predisposition and protection. Because the cytotoxic T lymphocyte antigen 4 (CTLA4) alanine-17 encoded by the CTLA4 gene on chromosome 2q33 confers susceptibility to Graves' disease, as well as to type 1 (insulin-dependent)...
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