Article
Different targets for the fragile X-related proteins revealed by their distinct nuclear localizations.
Human molecular genetics - 1 May 1999
Tamanini F, Bontekoe C, Bakker C E, van Unen L, Anar B, Willemsen R, Yoshida M, Galjaard H, Oostra B A, Hoogeveen A T
Abstract excerpt
Fragile X syndrome is caused by the absence of the fragile X mental retardation protein (FMRP). FMRP and its structural homologues FXR1P and FXR2P form a family of RNA-binding proteins (FXR proteins). The three proteins associate with polyribosomes as cytoplasmic mRNP particles. Here we show that small amounts of FMRP, FXR1P and FXR2P shuttle between cytoplasm and nucleus. Mutant FMRP of a severely affected...
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