Article

Loss of FXR1 and FXR2 promotes accumulation of TDP-43 in aging-related stress granules

2025-10-27

Abstract excerpt

Cytoplasmic mislocalization and aggregation of the RNA-binding protein TDP-43 in vulnerable neurons may accompany the primary neuropathology of various neurodegenerative diseases, or represent the hallmark of others, such as amyotrophic lateral sclerosis. Aging is the major risk factor for neurodegeneration, and sufficient to induce accumulation of TDP-43 in chronic cytoplasmic stress granules possibly further mat...

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Literature Corpus work: 7ea27a42-d532-5650-8ead-42caa31389c3
DOI: 10.1101/2025.10.27.684798

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