Article
FMRP associates with polyribosomes as an mRNP, and the I304N mutation of severe fragile X syndrome abolishes this association.
Molecular cell - 1 Dec 1997
Feng Y, Absher D, Eberhart D E, Brown V, Malter H E, Warren S T
Abstract excerpt
Fragile X mental retardation is caused by the lack of FMRP, a selective RNA-binding protein associated with ribosomes. A missense mutation, I304N, has been found to result in an unusually severe phenotype. We show here that normal FMRP associates with elongating polyribosomes via large mRNP parti...
Topics
- Animals
- COS Cells
- Cell Line
- Fragile X Mental Retardation Protein
- Fragile X Syndrome
- Humans
- Lymphocytes
- Mutagenesis
- Nerve Tissue Proteins
- Phenotype
- Polyribosomes
- Protein Biosynthesis
- RNA, Messenger
- RNA-Binding Proteins
- Ribonucleoproteins