Article
Hprt mutant frequency and aromatic DNA adduct level in non-smoking and smoking lung cancer patients and population controls.
Carcinogenesis - 1 Mar 1999
Hou S M, Yang K, Nyberg F, Hemminki K, Pershagen G, Lambert B
Abstract excerpt
T cell cloning and 32P-post-labelling methods were used to study the mutant frequency (MF) at the hypoxanthine-guanine phosphoribosyl transferase (hprt) locus and the aromatic DNA adduct level (AL) in peripheral lymphocytes of newly diagnosed lung cancer patients (92 ever-smokers and 87 never-smokers) and matched population controls (82 ever-smokers and 79 never-smokers). Overall, the MF (total mean 20.6 x...
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