Article
C282Y and H63D mutations of HFE gene in patients with advanced alcoholic liver disease.
Revista espanola de enfermedades digestivas - 1 Mar 2001
Ropero Gradilla P, Villegas Martínez A, Fernández Arquero M, García-Agúndez J A, González Fernández F A, Benítez Rodríguez J, Díaz-Rubio M, de la Concha E G, Ladero Quesada J M
Abstract excerpt
OBJECTIVE: To test the hypothesis that the heterozygous state for HFE gene mutations involved in the pathogenesis of hemochromatosis, that may induce an increase of hepatic iron content, may aggravate the liver damage induced by prolonged and excessive use of ethanol. PATIENTS AND METHODS: C282Y and H63D mutations of HFE gene were identified through polymerase chain reaction (PCR) on leukocyte DNA, in 125...
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