Article
Polymerization of tau peptides into fibrillar structures. The effect of FTDP-17 mutations.
FEBS letters - 5 Mar 1999
Arrasate M, Pérez M, Armas-Portela R, Avila J
Abstract excerpt
The peptides corresponding to the four repeats found in the microtubule binding region of tau protein were synthesized and their ability for self-aggregation in presence of heparin or chondroitin sulfate was measured. Mainly, only the peptide containing the third tau repeat is able to form polymers in a high proportion. Additionally, the peptide containing the second repeat aggregates with a very low efficiency....
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