Article
Assembly of two distinct dimers and higher-order oligomers from full-length tau.
The European journal of neuroscience - 1 May 2007
Sahara Naruhiko, Maeda Sumihiro, Murayama Miyuki, Suzuki Takehiro, Dohmae Naoshi, Yen Shu-Hui, Takashima Akihiko
Abstract excerpt
Abnormal accumulation of tau as filamentous structures is a neuropathological hallmark of neurodegenerative diseases referred to as tauopathies. Little is known about the role of native cysteine residues in tau assembly because their substitution with other amino acids has no effect on tau filame...
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