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Article

The N-terminus of PrP is responsible for interacting with tubulin and fCJD related PrP mutants possess stronger inhibitive effect on microtubule assembly in vitro.

Archives of biochemistry and biophysics - 1 Feb 2008

Dong Chen-Fang, Shi Song, Wang Xiao-Fan, An Run, Li Ping, Chen Jian-Ming, Wang Xin, Wang Gui-Rong, Shan Bing, Zhang Bao-Yun, Han Jun, Dong Xiao-Ping

Abstract excerpt

Microtubule dynamics is essential for many vital cellular processes such as in intracellular transport, metabolism, and cell division. Some evidences demonstrate that PrP may associate with microtubular cytoskeleton and its major component, tubulin. In the present study, the molecular interaction between PrP and tubulin was confirmed using pull-down assays, immunoprecipitation and ELISA. The interacting regions...

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Identifiers

PMID: 18037369
DOI: 10.1016/j.abb.2007.11.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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