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Article

Mutually compensatory mutations during evolution of the tetramerization domain of tumor suppressor p53 lead to impaired hetero-oligomerization.

Proceedings of the National Academy of Sciences of the United States of America - 30 Mar 1999

Mateu M G, Fersht A R

Abstract excerpt

We have measured the stability and stoichiometry of variants of the human p53 tetramerization domain to assess the effects of mutation on homo- and hetero-oligomerization. The residues chosen for mutation were those in the hydrophobic core that we had previously found to be critical for its stability but are not conserved in human p73 or p51 or in p53-related proteins from invertebrates or vertebrates. The...

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Identifiers

PMID: 10097082
DOI: 10.1073/pnas.96.7.3595
PMCID: PMC22339

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Source receipt: pubmed, retrieved 7 Sept 2026.

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