Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

p53 mutations predict non-small cell lung carcinoma response to radiotherapy.

Cancer letters - 29 Jan 1999

Matsuzoe D, Hideshima T, Kimura A, Inada K, Watanabe K, Akita Y, Kawahara K, Shirakusa T

Abstract excerpt

In vitro and animal studies, the effect of loss of p53 function on radiosensitivity is controversial. p21Waf1/Cip1 is a potent inhibitor of cyclin-dependent kinases and p21 gene polymorphisms are associated with some human cancers. We sought to determine whether p53 mutations or p21 polymorphisms affect response to radiotherapy in patients with recurrent non-small cell lung carcinoma (NSCLC). Thirty-four patients...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Non-Small-Cell Lung
Share to Cyclin-Dependent Kinase Inhibitor p21

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclins

Share to Genes, p53

Share to Lung Neoplasms

Share to Neoplasm Recurrence, Local

Share to Polymorphism, Restriction Fragment Length

Share to Radiation Tolerance

Source

Identifiers

PMID: 10096428
DOI: 10.1016/s0304-3835(98)00292-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

p53 mutations predict non-small cell lung carcinoma response to radiotherapy.PMID 10096428Read ↗

The survival outcomes of patients with resected non-small cell lung cancer differ according to EGFR mutations and the P21 expression.Semantic proximity Read ↗

p53 gene mutations in non-small-cell lung cancer cell lines and their correlation with the presence of ras mutations and clinical features.Semantic proximity Read ↗

p53 mutations do not predict response to paclitaxel/radiation for nonsmall cell lung carcinoma.Semantic proximity Read ↗

p53 gene mutations and p21 protein expression induced independently of p53, by TGF-beta and gamma-rays in squamous cell carcinoma cells.Semantic proximity Read ↗

Prognostic and predictive importance of p53 and RAS for adjuvant chemotherapy in non small-cell lung cancer.Semantic proximity Read ↗

In vivo influence of p53 status on proliferation and chemoradiosensitivity in non-small-cell lung cancer.Semantic proximity Read ↗

p53 modulates radiation sensitivity independent of p21 transcriptional activation.Semantic proximity Read ↗

Loss of p53 gene mutation after irradiation is associated with increased aggressiveness in recurring head and neck cancer.Semantic proximity Read ↗

p53 and ras gene mutations in lung cancer: implications for smoking and occupational exposures.Semantic proximity Read ↗

p21WAF1 mutations and human malignancies.Semantic proximity Read ↗

Mutations of the p53 gene as a predictor of poor prognosis in patients with non-small-cell lung cancer.Semantic proximity Read ↗

Assessing the Radiation Response of Lung Cancer with Different Gene Mutations Using Genetically Engineered MiceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.