Article
A novel 8-bp insertion in codon 281 of p53 in a patient with acute lymphoblastic leukaemia and 2 separate leukaemic clones. Mutations in brief no. 219. Online.
Human mutation - 1 Jan 1999
Dang R K, Anthony R S, Craig J I, Parker A C
Abstract excerpt
We report a novel p53 insertion in a case of aggressive acute lymphoblastic leukaemia in a 16 year old male, in which 2 separate leukaemic clones were previously identified by T-cell receptor sigma and immunoglobulin heavy chain gene rearrangement studies. Initial p53 mutation screening of blast cells from 29 patients with acute leukaemia by PCR-denaturing gradient gel electrophoresis showed that 2 had a silent...
Topics
- Adolescent
- Clone Cells
- Codon
- DNA Transposable Elements
- Humans
- Male
- Mutation
- Precursor Cell Lymphoblastic Leukemia-Lymphoma
- Tumor Cells, Cultured
- Tumor Suppressor Protein p53