Article
Comparative rates of nucleotide sequence variation in the hypervariable region of E1/E2 and the NS5b region of hepatitis C virus in patients with a spectrum of liver disease resulting from a common source of infection.
Virology - 30 Sept 2002
Duffy Margaret, Salemi Marco, Sheehy Noreen, Vandamme Anne-Mieke, Hegarty John, Curry Michael, Nolan Niamh, Kelleher Dermot, McKiernan Susan, Hall William W
Abstract excerpt
The association of the severity of liver disease and the molecular evolution of hepatitis C virus (HCV) during chronic infection remains unclear and controversial. To address this we have studied the interpatient variability in the nucleotide sequence of two regions of the HCV genome, E1/E2, which contain the hypervariable region 1 and the nonstructural NS5b region, in a cohort of Irish female patients who were...
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