Article
Immunogenetics of mixed connective tissue disease in a Mexican Mestizo population.
Clinical and experimental rheumatology - 1 Jan 2000
Weckmann A L, Granados J, Cardiel M H, Andrade F, Vargas-Alarcón G, Alcocer-Varela J, Alarcón-Segovia D
Abstract excerpt
OBJECTIVE: The aim of this study was to determine the HLA antigens in Mexican Mestizo patients with mixed connective tissue disease (MCTD). METHODS: We studied 30 patients with MCTD and 99 healthy controls. HLA-A, -B, and -DQ antigens were typed by microlymphocytotoxicity assays. DRB1, DQA1 and DQB1 alleles were oligotyped. RESULTS: HLA-A2 and HLA-B35 were the most frequent MHC class I alleles in MCTD patients,...
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