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Article

Predisposition of HLA-DRB104:01/15 heterozygous genotypes to Japanese mixed connective tissue disease.

Scientific reports - 15 Jun 2022

Oka Shomi, Higuchi Takashi, Furukawa Hiroshi, Shimada Kota, Hashimoto Atsushi, Komiya Akiko, Matsui Toshihiro, Fukui Naoshi, Suematsu Eiichi, Ohno Shigeru, Kono Hajime, Katayama Masao, Nagaoka Shouhei, Migita Kiyoshi, Tohma Shigeto

Abstract excerpt

Mixed connective tissue disease (MCTD) is a rare systemic autoimmune disease characterized by the production of anti-U1 ribonucleoprotein antibodies and systemic symptoms similar to those of some other autoimmune diseases. HLA-DRB1 polymorphisms are important genetic risk factors for MCTD, but precise associations of DRB1 genotypes with MCTD have not been reported in Japanese people. Genotyping of HLA-DRB1 and...

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Identifiers

PMID: 35705662
DOI: 10.1038/s41598-022-14116-x
PMCID: PMC9200795

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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