Article
Difference in HLA-linked genetic background between mixed connective tissue disease and systemic lupus erythematosus.
Tissue antigens - 1 Jan 1993
Dong R P, Kimura A, Hashimoto H, Akizuki M, Nishimura Y, Sasazuki T
Abstract excerpt
We have typed 64 Japanese patients with mixed connective tissue disease (MCTD) and 53 Japanese patients with systemic lupus erythematosus (SLE) for HLA-DRB1, DRB3, DRB4, DRB5, DQA1, DQB1, and DPB1 genes by the HLA-DNA typing method using the PCR-SSOP technique. Frequencies of HLA-DRB1*0401, DRB1*0901, DRB4*0101, and DQA1*03 were increased and those of HLA-DRB1*0405 and DQB1*0401 were decreased in the patients...
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