Article
Association of HLA-DRB1 alleles with susceptibility to mixed connective tissue disease in Polish patients.
HLA - 1 Jan 2016
Paradowska-Gorycka A, Stypińska B, Olesińska M, Felis-Giemza A, Mańczak M, Czuszynska Z, Zdrojewski Z, Wojciechowicz J, Jurkowska M
Abstract excerpt
Mixed connective tissue disease (MCTD) is a systemic autoimmune disease, originally defined as a connective tissue inflammatory syndrome with overlapping features of systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), polymyositis/dermatomyositis (PM/DM) and systemic sclerosis (SSc), characterized by the presence of antibodies against components of the U1 small nuclear ribonucleoprotein (U1snRNP). The...
Topics
- Alleles
- Arthritis, Rheumatoid
- Autoantibodies
- Case-Control Studies
- Dermatomyositis
- Diagnosis, Differential
- Female
- Gene Expression
- Gene Frequency
- Genetic Predisposition to Disease
- HLA-DRB1 Chains
- Heterozygote
- Humans