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Article

Mixed connective tissue disease in siblings.

Arthritis and rheumatism - 1 Jan 2000

Horn J R, Kapur J J, Walker S E

Abstract excerpt

Mixed connective tissue disease (MCTD) was diagnosed in a brother and sister, and 18 additional family members spanning three generations were studied to detect evidence of autoimmune disease. Symptoms or signs of MCTD without complete expression of the disease were found in 8 relatives of the original cases. Antibodies to ribonucleoprotein and high-titer antinuclear antibodies were found only in the affected...

Topics

Adult
Antibodies, Antinuclear
Child
Child, Preschool
Female
Genotype
HLA Antigens
Humans
Male
Middle Aged
Mixed Connective Tissue Disease
Pedigree
Rheumatoid Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 310679
DOI: 10.1002/art.1780210617

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-310679-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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