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Molecular and genetic toxicology of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP).

Mutation research - 30 Sept 2002

Gooderham Nigel J, Zhu Huijun, Lauber Sandra, Boyce Antony, Creton Stuart

Abstract excerpt

The heterocyclic amine 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), formed when meat containing food is cooked, induces cancer of the colon, prostate and mammary gland of rats, tumours that are strongly associated with a Western diet. After consumption of a meat meal, PhIP is rapidly absorbed, metabolised and bioactivated to DNA damaging species. Thus, PhIP should be considered as a candidate...

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Identifiers

PMID: 12351148
DOI: 10.1016/s0027-5107(02)00155-0

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