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Article

Interferon Regulatory Factor 2 Represses the Epstein-Barr Virus Bam HI Q Latency Promoter in Type III Latency

1 Apr 1999

Abstract excerpt

Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA-1) is the essential protein for maintenance of the EBV episome and establishment of latency. The BamHI Q promoter (Qp) is used for the transcription of EBNA-1 mRNA in type I and type II latency, which are EBV infection states exemplified by Burkitt's lymphoma and nasopharyngeal carcinoma. However, Qp is inactive in type III latency, and other promoters (the BamHI C...

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PMID: 10082588
DOI: 10.1128/mcb.19.4.3216

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