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Regulation of Epstein–Barr virus reactivation from latency

1 May 2014

Abstract excerpt

The Epstein-Barr virus (EBV) is a human gamma-herpesvirus that is implicated in various types of proliferative diseases. Upon infection, it predominantly establishes latency in B cells and cannot ever be eradicated; it persists for the host's lifetime. Reactivation of the virus from latency depends on expression of the viral immediate-early gene, BamHI Z fragment leftward open reading frame 1 (BZLF1). The BZLF1...

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PMID: 24786491
DOI: 10.1111/1348-0421.12155

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