Article
Host cell-dependent expression of latent Epstein-Barr virus genomes: regulation by DNA methylation.
Advances in cancer research - 1 Jan 2003
Li Hul, Minarovits Janos
Abstract excerpt
Epstein-Barr virus (EBV) is a ubiquitous human gammaherpesvirus associated with a wide spectrum of malignant neoplasms. Expression of latent (growth transformation-associated) EBV genes is host cell specific. Transcripts for EBV-encoded nuclear antigens (EBNAs) are initiated at one of the alternative promoters: Wp, Cp (for EBNA1-6), or Qp (for EBNA1 only). Wp is active shortly after EBV infection of human B cells...
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