The Epstein–Barr virus latency Bam HI-Q promoter is positively regulated by STATs and Zta interference with JAK/STAT activation leads to loss of Bam HI-Q promoter activity

Abstract excerpt

In Epstein-Barr virus (EBV)-associated tumors in nonimmunocompromised patients, EBV gene expression is highly restricted. EBV-encoded nuclear antigen (EBNA)-1 is expressed, whereas the immunogenic and proliferative EBNAs are not. This pattern of EBNA expression is generated by usage of the BamHI-Q promoter (Qp). We have determined that the JAK/STAT pathway positively regulates Qp activity. In...

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