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Article

Direct inhibition of TNF-α promoter activity by Fanconi anemia protein FANCD2.

PloS one - 1 Jan 2011

Matsushita Nobuko, Endo Yujiro, Sato Koichi, Kurumizaka Hitoshi, Yamashita Takayuki, Takata Minoru, Yanagi Shigeru

Abstract excerpt

Fanconi anemia (FA), an inherited disease, is associated with progressive bone marrow failure, predisposition to cancer, and genomic instability. Genes corresponding to 15 identified FA complementation groups have been cloned, and each gene product functions in the response to DNA damage induced by cross-linking agents and/or in protection against genome instability. Interestingly, overproduction of inflammatory...

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Identifiers

PMID: 21912593
DOI: 10.1371/journal.pone.0023324
PMCID: PMC3166142

Genes

TNF
FANCD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Direct inhibition of TNF-α promoter activity by Fanconi anemia protein FANCD2.PMID 21912593Read ↗

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