Article
In vitro phenotypic correction of hematopoietic progenitors from Fanconi anemia group A knockout mice.
Blood - 15 Sept 2002
Río Paula, Segovia José Carlos, Hanenberg Helmut, Casado José Antonio, Martínez Jesús, Göttsche Kerstin, Cheng Ngan Ching, Van de Vrugt Henri J, Arwert Fré, Joenje Hans, Bueren Juan A
Abstract excerpt
Fanconi anemia (FA) is a rare autosomal recessive disease, characterized by bone marrow failure and cancer predisposition. So far, 8 complementation groups have been identified, although mutations in FANCA account for the disease in the majority of FA patients. In this study we characterized the hematopoietic phenotype of a Fanca knockout mouse model and corrected the main phenotypic characteristics of the bone...
Topics
- Animals
- Apoptosis
- Bone Marrow Cells
- Cell Culture Techniques
- DNA-Binding Proteins
- Fanconi Anemia
- Fanconi Anemia Complementation Group A Protein
- Genetic Therapy
- Genetic Vectors
- Hematopoietic Stem Cells
- Humans
- Mice
- Mice, Inbred C57BL