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Article

Prox1 maintains muscle structure and growth in the developing heart

18 Dec 2008

Abstract excerpt

Impaired cardiac muscle growth and aberrant myocyte arrangement underlie congenital heart disease and cardiomyopathy. We show that cardiac-specific inactivation of the murine homeobox transcription factor Prox1 results in the disruption of expression and localisation of sarcomeric proteins, gross myofibril disarray and growth-retarded hearts. Furthermore, we demonstrate that Prox1 is required for direct...

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PMID: 19091769
DOI: 10.1242/dev.030007

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