Article
True pedigree errors more frequent than apparent errors for single nucleotide polymorphisms.
Human heredity - 1 Mar 1999
Gordon D, Heath S C, Ott J
Abstract excerpt
Single nucleotide polymorphisms (SNPs) are currently being developed for use in disequilibrium analyses. These SNPs consist of two alleles with varying degrees of polymorphism. A natural design for use with SNPs is the 'haplotype relative risk' sampling design in which a father, mother, and child are typed at an SNP locus. Given such a trio of genotypes, we ask: what is the probability that a pedigree error (a...
Topics
- Alleles
- Genotype
- Humans
- Models, Statistical
- Mutation
- Pedigree
- Polymorphism, Genetic