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Article

Combinatorial therapeutic activation with heparin and AICAR stimulates additive effects on utrophin A expression in dystrophic muscles

22 Oct 2015

Abstract excerpt

Upregulation of utrophin A is an attractive therapeutic strategy for treating Duchenne muscular dystrophy (DMD). Over the years, several studies revealed that utrophin A is regulated by multiple transcriptional and post-transcriptional mechanisms, and that pharmacological modulation of these pathways stimulates utrophin A expression in dystrophic muscle. In particular, we recently showed that activation of p38...

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PMID: 26494902
DOI: 10.1093/hmg/ddv444

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Combinatorial therapeutic activation with heparin and AICAR stimulates additive effects on utrophin A expression in dystrophic musclesPMID 26494902Read ↗

Activation of p38 signaling increases utrophin A expression in skeletal muscle via the RNA-binding protein KSRP and inhibition of AU-rich element-mediated mRNA decay: implications for novel DMD therapeuticsSemantic proximity Read ↗

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Biglycan recruits utrophin to the sarcolemma and counters dystrophic pathology in mdx miceSemantic proximity Read ↗

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