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Article

Linkage analysis and detection of somatic, postzygous RB1 mutations in Serbian retinoblastoma patients.

Journal of B.U.ON. : official journal of the Balkan Union of Oncology - 1 Jan 2000

Kontic M, Palacios I, Kontic M, Alonso J, Pestana A

Abstract excerpt

PURPOSE: The etiology of retinoblastoma (RB) is mutational inactivation of two RB1 alleles, the prototype of tumor suppressor gene. The aim of this research was to reveal sporadic, postzygous RB1 gene mutations, in particular loss of heterozygosity (LOH), from formalin-fixed, paraffin-embedded tumor samples in RB patients, as well as tracking RB1 allele inheritance in 10 RB families. METHODS: The mutational...

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PMID: 21674866

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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