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Article

Cyclin-dependent kinase control of centrosome duplication

16 Mar 1999

Abstract excerpt

Centrosomes nucleate microtubules and duplicate once per cell cycle. This duplication and subsequent segregation in mitosis results in maintenance of the one centrosome/cell ratio. Centrosome duplication occurs during the G1/S transition in somatic cells and must be coupled to the events of the nuclear cell cycle; failure to coordinate duplication and mitosis results in abnormal numbers of centrosomes and...

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PMID: 10077594
DOI: 10.1073/pnas.96.6.2817

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