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Article

Requirement of Cdk2-Cyclin E Activity for Repeated Centrosome Reproduction in <i>Xenopus</i> Egg Extracts

5 Feb 1999

Abstract excerpt

The abnormally high number of centrosomes found in many human tumor cells can lead directly to aneuploidy and genomic instability through the formation of multipolar mitotic spindles. To facilitate investigation of the mechanisms that control centrosome reproduction, a frog egg extract arrested in S phase of the cell cycle that supported repeated assembly of daughter centrosomes was developed. Multiple rounds of...

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PMID: 9933170
DOI: 10.1126/science.283.5403.851

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