Article
Metabolic properties of normal and mutant mannan-binding proteins in mouse plasma.
Biochemical and biophysical research communications - 5 Mar 1999
Naito H, Ma Y, Uemura K, Arano Y, Kawasaki T
Abstract excerpt
Human mannan-binding protein (MBP) is a serum lectin involved in innate immunity. MBP activates the complement pathway through its interaction with mannose-rich carbohydrates on various microorganisms and a common opsonic defect has been shown to be associated with a low serum concentration of MBP. This low serum concentration is closely associated with a single base mutation in codon 52, 54 or 57 of the human...
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