Article
Intravascular metabolism of normal and mutant mouse immunoglobulin molecules.
European journal of immunology - 1 Sept 1990
Pollock R R, French D L, Metlay J P, Birshtein B K, Scharff M D
Abstract excerpt
The metabolism of IgG immunoglobulins in the body is tightly regulated in order to maintain their intravascular concentration. Different subclasses may have different intravascular half-lives, and in the mouse, passively administered IgG2b disappears from the circulation more rapidly than IgG2a. We have attempted to localize the sequences in the constant region which are responsible for this difference by...
Topics
- Animals
- Half-Life
- Immunoglobulin G
- Immunoglobulin Heavy Chains
- Immunoglobulins
- Mice
- Mice, Inbred BALB C
- Mutation