The Gly-54-->Asp allelic form of human mannose-binding protein (MBP) fails to bind MBP-associated serine protease.

doi:10.1042/bj3111021

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Article

The Gly-54-->Asp allelic form of human mannose-binding protein (MBP) fails to bind MBP-associated serine protease.

The Biochemical journal - 1 Nov 1995

Matsushita M, Ezekowitz R A, Fujita T

Abstract excerpt

The human mannose-binding protein (MBP) is a pattern recognition molecule that appears to play a role in initial host defence. MBP activates the complement cascade and it may act as an opsonin both in the absence and in the presence of complement. A number of distinct MBP allelic forms exist in d...

Topics

Alleles
Animals
Aspartic Acid
Carrier Proteins
Complement Activation
Glycine
Humans
Mannose
Mannose-Binding Lectins
Mannose-Binding Protein-Associated Serine Proteases
Protein Binding
Recombinant Proteins
Serine Endopeptidases
Sheep

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